Which antibiotic is contraindicated in large-breed dogs?

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Study for the Program for the Assessment of Veterinary Education (PAVE) Exam. Prepare with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

Which antibiotic is contraindicated in large-breed dogs?

Explanation:
Fluoroquinolones carry a risk to developing joints. In skeletally immature animals, especially large-breed puppies that are growing rapidly, enrofloxacin can cause irreversible cartilage erosion in weight-bearing joints. Because of this potential for lasting orthopedic damage, enrofloxacin is contraindicated in growing large-breed dogs. Other antibiotics listed do not have the same growth-plate cartilage toxicity risk and are not contraindicated for large-breed puppies on the basis of this safety concern.

Fluoroquinolones carry a risk to developing joints. In skeletally immature animals, especially large-breed puppies that are growing rapidly, enrofloxacin can cause irreversible cartilage erosion in weight-bearing joints. Because of this potential for lasting orthopedic damage, enrofloxacin is contraindicated in growing large-breed dogs. Other antibiotics listed do not have the same growth-plate cartilage toxicity risk and are not contraindicated for large-breed puppies on the basis of this safety concern.

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