Which rodent is predisposed to pregnancy toxemia?

Which rodent is predisposed to pregnancy toxemia?

• A. Rats
• B. Guinea pigs
• C. Mice
• D. Hamsters

Answer: (B)

Pregnancy toxemia occurs when the energy needs of late pregnancy or lactation outpace what the animal is taking in, leading to a negative energy balance. The body attempts to fuel the fetus by mobilizing fat, which raises ketone bodies and can overwhelm the liver, causing hepatic lipidosis and systemic illness if not corrected. Guinea pigs are especially susceptible because their energy demands surge late in pregnancy, and they are prone to reduced intake due to dental issues, stress, or other illnesses. They rely on dietary carbohydrates to maintain blood glucose, so when intake drops, they quickly become hypoglycemic and ketotic, with fat accumulating in the liver. While ketosis can occur in other small mammals under severe nutritional stress, guinea pigs are the species most classically predisposed to this condition.

Pregnancy toxemia occurs when the energy needs of late pregnancy or lactation outpace what the animal is taking in, leading to a negative energy balance. The body attempts to fuel the fetus by mobilizing fat, which raises ketone bodies and can overwhelm the liver, causing hepatic lipidosis and systemic illness if not corrected.

Guinea pigs are especially susceptible because their energy demands surge late in pregnancy, and they are prone to reduced intake due to dental issues, stress, or other illnesses. They rely on dietary carbohydrates to maintain blood glucose, so when intake drops, they quickly become hypoglycemic and ketotic, with fat accumulating in the liver. While ketosis can occur in other small mammals under severe nutritional stress, guinea pigs are the species most classically predisposed to this condition.